The term metaphysics was formed at a time when physics and the physical categories constituted the whole of natural science and to describe the field of thought beyond physics. With the development of other fields of knowledge such as the biological and the historical, it has of necessity acquired a much broader meaning. It describes a field of speculative thought which lies beyond the categories of any of these sciences. In the present context the metaphysical is the meta-historical.

The Search for the Legacy of the USPHS Syphilis Study at Tuskegee is a collection of essays from experts in a variety of fields seeking to redefine the legacy of the infamous Tuskegee Syphilis Study. The essayists place the legacy of the study within the evolution of racial and ethnic relations in the United States. Contributors include two leading historians on the study, two former United States Surgeons General, and other prominent scholars from a wide range of fields.

Self‐renewal and differentiation of stem cells are tightly regulated processes subject to intrinsic and extrinsic signals. Molecular chaperones and co‐chaperones, especially heat shock proteins (Hsp), are ubiquitous molecules involved in the modulation of protein conformational and complexation states. The function of Hsp, which are typically associated with stress response and tolerance, is well characterized in differentiated cells, while their role in stem cells remains unclear. It appears that embryonic stem cells exhibit increased stress tolerance and concomitant high levels of chaperone (...) expression. This review critically evaluates stem cell research from a molecular chaperone perspective. Furthermore, we propose a model of chaperone‐modulated self‐renewal in mouse embryonic stem cells. (shrink)

Growing literature has linked attention bias variability to the experience and treatment of posttraumatic stress disorder. Unlike assessments of attention bias in only one direction, A...

Heidegger, Sartre and the later existentialist philosophers inherited a world, it has been said, from which "God is absent". Contemporary philosophy begins in the momentous questioning of the Christian experience by such nineteenth-century figures as Nietzsche and Dosteyevsky. But if existentialism is in some respects a beginning-again, it is in other respects linked to the classical world out of which Christianity arose and to certain themes in the writings of ancient and medieval Christians. Renewal and innovation converge. Addressing themselves to (...) the general reader, the three author-philosophers consider both the contemporary and the perennial. [Book jacket]. (shrink)